RESEARCH PROJECTS
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A 3D Neurosterol Atlas of Mouse Brain
Contracted centre: University of Edinburgh
Status: Active
Duration: 03 years 03 months
A 3D Neurosterol Atlas of Mouse Brain
Contracted centre: Swansea University
Status: Active
Duration: 03 years 03 months
A 3D Neurosterol Atlas of Mouse Brain
Contracted centre: University of Edinburgh
Status: Active
Duration: 02 years 03 months
A Biological Framework of Reduced Physical and Social Activity across the Lifespan
Contracted centre: University of Birmingham
Status: Active
Duration: 04 years 01 months
A dual DLS and SEC-MALS instrumentation to characterize protein oligomerization for structural and mechanistic biology
Contracted centre: King's College London
Status: Active
Duration: 00 years 11 months
A multi-scale computational model of brain blood flow: enhancing MRI for assessing brain health
Contracted centre: Cardiff University
Status: Active
Duration: 03 years 06 months
A new collaborative ultra-high field MRI facility for dementia and neuroscience research
Contracted centre: University of Cambridge
Status: Active
Duration: 01 years 05 months
A New Method to Develop PET Ligands for Protein Aggregates in Neurodegenerative Disorders Using Soluble Brain-Derived Aggregates
Contracted centre: University of Cambridge
Status: Active
Duration: 03 years 08 months
Advancing understanding of anaesthesia and analgesia in the zebrafish
Contracted centre: University of Exeter
Status: Active
Duration: 02 years 11 months
Alcohol consumption and brain health
Contracted centre: University of Oxford
Status: Active
Duration: 05 years 00 months
Altered RNA metabolism in neurodegeneration
Contracted centre: King's College London
Status: Active
Duration: 00 years 00 months
Alzheimer s disease and the frontotemporal dementias: an integrated clinical neuroscience approach
Contracted centre: University of Cambridge
Status: Completed
Duration: 10 years 03 months
An integrated MRI tool to map brain microvascular and metabolic function: improving imaging diagnostics for human brain disease
Contracted centre: Cardiff University
Status: Active
Duration: 05 years 02 months
An investigation into the role and regulation of BACE1.
Contracted centre: University of Leeds
Status: Active
Duration: 02 years 11 months
An investigation into the role and regulation of BACE1.
Contracted centre: University of Leeds
Status: Active
Duration: 02 years 11 months
Analysis of neurodegeneration
Contracted centre: University College London
Status: Active
Duration: 00 years 00 months
Anti-memories through compartmentalised activity in a single neuron in a Drosophila memory centre
Contracted centre: University of Sheffield
Status: Completed
Duration: 03 years 04 months
Architecture, function and dysfunction of astrocyte-vasculature interactions
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Are multiple mechanisms involved in FTLD-TDP pathologensis: will one drug fit all?
Contracted centre: University College London
Status: Completed
Duration: 03 years 11 months
Are neuronal catenins involved in the synaptopathology of Alzheimer’s disease?
Contracted centre: University of Bristol
Status: Active
Duration: 00 years 00 months
Assessing the health of ageing blood vessels in the brain using fMRI
Contracted centre: Cardiff University
Status: Completed
Duration: 05 years 08 months
Astrocytes as an upstream modulator and downstream effector of neurodegenerative pathology
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Atherosclerosis, the brain and vascular dementia – the role of inflammation in neurovascular function
Contracted centre: University of Sheffield
Status: Active
Duration: 03 years 00 months
Bacterial sphingolipids – revealing hidden biosynthetic pathways of key players in host-microbe interactions.
Contracted centre: Newcastle University
Status: Active
Duration: 02 years 11 months
Bacterial sphingolipids – revealing hidden biosynthetic pathways of key players in host-microbe interactions.
Contracted centre: University of Edinburgh
Status: Active
Duration: 02 years 11 months
Beyond drugs: Non-invasive focused ultrasound brain stimulation as a novel intervention for mental health
Contracted centre: University of Nottingham
Status: Active
Duration: 01 years 08 months
Bilateral BBSRC-FAPESP: A “speciomic” toolkit to investigate fatty acid-mediated changes in plasma zinc speciation and their physiological effects
Contracted centre: University of St Andrews
Status: Active
Duration: 02 years 11 months
Biostatistics and functional genomics
Contracted centre: University of Cardiff
Status: Active
Duration: 00 years 00 months
Biostatistics and functional genomics in dementia
Contracted centre: UK Dementia Research Institute at Cardiff University
Status: Active
Duration: 83 years 03 months
Blocking α-synuclein associated toxicity in Parkinson’s disease (and associated dementia)
Contracted centre: University of Bath
Status: Active
Duration: 00 years 00 months
Blood-brain barrier dysfunction and risk of dementia following blood-stream infections
Contracted centre: Cardiff University
Status: Active
Duration: 02 years 11 months
Brain signatures of auditory information processing in the Degenerative Dementias.
Contracted centre: University College London
Status: Completed
Duration: 03 years 11 months
Building a continuous and dynamic but neglected cell compartment: axonal endoplasmic reticulum
Contracted centre: University of Cambridge
Status: Completed
Duration: 04 years 04 months
Building spatial maps from visual and self-motion inputs
Contracted centre: Queen Mary University of London
Status: Active
Duration: 03 years 03 months
Can damage to brain blood vessels explain symptoms of atrial fibrillation?
Contracted centre: University of Birmingham
Status: Completed
Duration: 02 years 00 months
Can leptin, the anti-obesity hormone, protect brain cells?
Contracted centre: University of Dundee
Status: Active
Duration: 00 years 00 months
Cardiovascular mechanisms linked to cerebral amyloid β deposition and cognitive decline: A substudy of INSIGHT 46
Contracted centre: University College London
Status: Completed
Duration: 02 years 07 months
Centre for prevention of stroke and dementia.
Contracted centre: University of Oxford
Status: Active
Duration: 06 years 02 months
Cerebrovascular and inflamm-ageing link to neurodegeneration and dementia
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Changes in gut microbe-host interactions and their impact beyond the gut
Contracted centre: Quadram Institute Bioscience
Status: Active
Duration: 02 years 02 months
Cholesterol esters of oligodendrocytes in developmental and ageing brain
Contracted centre: University College London
Status: Completed
Duration: 03 years 11 months
Cholesterol esters of oligodendrocytes in developmental and ageing brain
Contracted centre: University College London
Status: Completed
Duration: 03 years 11 months
Circadian dysfunction in the early stages of Alzheimer’s disease – Sleep theme
Contracted centre: Imperial College London
Status: Active
Duration: 00 years 00 months
Circuit-level mechanisms of memory consolidation
Contracted centre: University of Oxford
Status: Completed
Duration: 03 years 08 months
Circuit-level mechanisms of memory consolidation
Contracted centre: University of Oxford
Status: Completed
Duration: 03 years 08 months
Citizen Science To Achieve Coproduction at Scale
Contracted centre: University of Nottingham
Status: Active
Duration: 02 years 05 months
Comparative and functional analysis of brain lymphatic endothelial cells
Contracted centre: University College London
Status: Completed
Duration: 03 years 09 months
Complement in Alzheimer’s disease: from gene discovery to mechanisms and better drugs
Contracted centre: University of Cardiff
Status: Active
Duration: 00 years 00 months
Computational modelling for understanding mechanisms of Alzheimer’s disease progression
Contracted centre: University College London
Status: Active
Duration: 03 years 11 months
Computational Modelling of Neural Network Growth and Dynamics
Contracted centre: Newcastle University
Status: Completed
Duration: 03 years 04 months
Connecting objects to places: functional investigation of projections from lateral to medial entorhinal cortex
Contracted centre: University of Edinburgh
Status: Active
Duration: 02 years 11 months
Consequences of ethnic differences in cardiometabolic disease in older age: the Southall And Brent Revisited (SABRE) tri-ethnic population cohort
Contracted centre: University College London
Status: Completed
Duration: 05 years 00 months
Cortical pathways and synaptic mechanisms for texture discrimination learning in rodents
Contracted centre: Cardiff University
Status: Completed
Duration: 02 years 11 months
CRISPR-Cas9 genetic screens for novel synaptic maintenance genes and therapeutic targets
Contracted centre: University of Cambridge
Status: Active
Duration: 00 years 00 months
Deciphering the cellular mechanism of seeded prion aggregation in neuronal cells
Contracted centre: University College London
Status: Active
Duration: 02 years 11 months
Deciphering the cellular mechanism of seeded prion aggregation in neuronal cells
Contracted centre: University College London
Status: Active
Duration: 02 years 11 months
Decision making in dementia
Contracted centre: MRC Cognition and Brain Sciences Unit
Status: Active
Duration: 83 years 05 months
Defining mechanisms and function of protein UFMylation
Contracted centre: University of Dundee
Status: Active
Duration: 02 years 11 months
Defining the role of myosin motor proteins and their cargo adaptors in cytokine secretion
Contracted centre: University of Cambridge
Status: Completed
Duration: 05 years 00 months
Defining the role of post-translational modifications of Frizzled-5 receptor: implications in cell signalling and synapse formation
Contracted centre: University College London
Status: Completed
Duration: 03 years 11 months
Determining the causal effects of lipid levels on risk of dementia: a triangulation of the available evidence and individual participant data meta-analysis
Contracted centre: University of Bristol
Status: Completed
Duration: 02 years 11 months
Determining the causes and consequences of brain amyloidosis, atrophy and cerebrovascular disease: a longitudinal amyloid-PET/MRI study of the MRC British 1946 birth cohort
Contracted centre: University College London
Status: Active
Duration: 05 years 00 months
Determining the membrane circadian clock across evolution
Contracted centre: University of Bristol
Status: Active
Duration: 02 years 11 months
Developing an evidence base for trials in genetic frontotemporal dementia – measures of disease onset and progression
Contracted centre: University College London
Status: Active
Duration: 03 years 11 months
Developing biosensors to detect infections and monitor dementia progression
Contracted centre: Imperial College London
Status: Active
Duration: 00 years 00 months
Developing new ways to study and test treatments for small vessel disease in vascular dementia
Contracted centre: University of Edinburgh
Status: Completed
Duration: 04 years 11 months
Developing the African Turquoise killifish (N. furzeri) as a model for Alzheimer’s Disease
Contracted centre: University of Bath
Status: Active
Duration: 00 years 11 months
Development and application of Rabies Virus-based approaches for genomic editing of neural circuits in healthy and diseased brain
Contracted centre: MRC Laboratory of Molecular Biology
Status: Active
Duration: 03 years 03 months
Development of an Enzymatic Organic Electrochemical Transistor for Studying Cerebral Cholesterol Metabolism in Alzheimer’s Pathology
Contracted centre: University of Cambridge
Status: Active
Duration: 03 years 11 months
Differential display proteomics for drug discovery and diagnostics for Alzheimer s disease
Contracted centre: King's College London
Status: Completed
Duration: 03 years 00 months
Dissecting macroglial-neuronal crosstalk in C9ORF72 Frontotemporal dementia/ amyotrophic lateral sclerosis
Contracted centre: UK Dementia Research Institute at University of Edinburgh
Status: Active
Duration: 83 years 03 months
Dissecting macroglial-neuronal crosstalk in C9ORF72 FTD/ALS
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Dissecting the neural components of the hippocampal cognitive map
Contracted centre: University College London
Status: Completed
Duration: 05 years 11 months
Dissecting the role of endothelial insulin-like growth factor-1 signalling in the vascular and metabolic complications of obesity-induced type 2 diabetes mellitus
Contracted centre: University of Leeds
Status: Completed
Duration: 03 years 00 months
Do astrocytes store more fat when our brain gets older: a new target for dementia?
Contracted centre: University of Nottingham
Status: Completed
Duration: 00 years 01 months
Does brain trauma cause premature ageing of the nervous system?
Contracted centre: University of Liverpool
Status: Active
Duration: 02 years 11 months
Downsized cell-dervied peptides as potent inhibitors of aS Toxicity
Contracted centre: University of Bath
Status: Completed
Duration: 04 years 03 months
Engineering novel amyloid biofilm based material for capture and degradation of micro-plastics
Contracted centre: University of Kent
Status: Active
Duration: 00 years 11 months
Enhancing cognition through the menopausal transition in at-risk ‘APOE4’ carriers by fatty acid and hormonal modulation.
Contracted centre: University of East Anglia
Status: Active
Duration: 02 years 11 months
Epidemiological neuropathology of dementia – The Cognitive Function and Ageing Neuropathology Study
Contracted centre: University of Sheffield
Status: Completed
Duration: 05 years 00 months
Epigenetic pathways in healthy ageing and neurodegeneration
Contracted centre: Imperial College London
Status: Active
Duration: 00 years 00 months
Epigenetic regulation of environmental and genetic risk in neurodegenerative disease
Contracted centre: Imperial College London
Status: Active
Duration: 00 years 00 months
Establishing a network to catalyse collaboration for reducing immune ageing (CARINA: CAtalyst Reducing ImmuNe Ageing)
Contracted centre: University College London
Status: Active
Duration: 01 years 11 months
Establishing selective autophagy as novel target for therapeutic interventions in neurodegenerative diseases
Contracted centre: Newcastle University
Status: Active
Duration: 03 years 06 months
Establishing the structure, regulation, and conservation of endothelial “kugeln”
Contracted centre: University of Sheffield
Status: Completed
Duration: 02 years 00 months
Evaluation of the tau aggreation detected by novel tau tracer, [18F]T807 PET in mild cognitive impairment subjects: a preliminary collaborative PET study
Contracted centre: Imperial College London
Status: Completed
Duration: 02 years 11 months
Feasibility study: To assess whether reducing periodontal infection (gum disease) slows the progression of cognitive impairment associated with Alzheimer’s disease.
Contracted centre: University Hospitals Bristol and Weston NHS Foundation Trust
Status: Completed
Duration: 02 years 11 months
From Patient to Bench and Back: Clinical Resources, Accelerating Therapies
Contracted centre: University College London
Status: Active
Duration: 00 years 00 months
Frontotemporal dementia and amyotrophic lateral sclerosis disease mechanisms
Contracted centre: University College London
Status: Active
Duration: 00 years 00 months
Functional analysis of stress-dependent RNA-enzyme interactions
Contracted centre: University of Surrey
Status: Completed
Duration: 03 years 06 months
Functional Consequences Of The Plant Epitranscriptome
Contracted centre: University of Nottingham
Status: Completed
Duration: 03 years 11 months
Functional specialization of RNP granules in RNA metabolism
Contracted centre: The University of Manchester
Status: Active
Duration: 02 years 11 months
Genetic mechanisms underlying tauopathies
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Glial-neuronal homeostatic mechanisms with amyloid pathology
Contracted centre: Imperial College London
Status: Active
Duration: 00 years 00 months
Global compRehensive Atlas of Peptide and Protein Abundance
Contracted centre: University of Liverpool
Status: Active
Duration: 02 years 11 months
Global compRehensive Atlas of Peptide and Protein Abundance
Contracted centre: EMBL - European Bioinformatics Institute
Status: Active
Duration: 02 years 11 months
Harnessing immunity to target protein aggregation.
Contracted centre: University of Cambridge
Status: Active
Duration: 00 years 00 months
HDHL- Combining vitamin E-functionalized chocolate with physical exercise to reduce the risk of protein-energy malnutrition in aged people (CHOKO-AGE)
Contracted centre: University of Liverpool
Status: Active
Duration: 02 years 11 months
High Resolution Mass Spectrometry to enhance hormonal profiling across the lifespan.
Contracted centre: University of Edinburgh
Status: Completed
Duration: 01 years 04 months
How are people with a cognitive impairment investigated, to understand the underlying cause of impairment?
Contracted centre: The University of Sheffield
Status: Completed
Duration: 00 years 06 months
How do individual differences in midlife adiposity and APOE genotype as risk factors for dementia affect brain structure and cognition? A cross-sectional MRI study
Contracted centre: Cardiff University
Status: Active
Duration: 00 years 00 months
How do microglia regulate myelin integrity and cognitive function in health and ageing?
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
How the ESCRT-III-like protein Vipp1 assembles polymeric super-structures to mitigate membrane stress
Contracted centre: Imperial College London
Status: Active
Duration: 03 years 11 months
Human stem cell models of Alzheimer’s disease
Contracted centre: University of Cambridge
Status: Completed
Duration: 05 years 11 months
Identification of novel pathways that induce autophagy to enable neuroprotection
Status: Active
Duration: 00 years 00 months
Identifying Disease Mechanisms Caused by Endocytic Genes in Late Onset Alzheimer’s Disease
Contracted centre: Cardiff University
Status: Active
Duration: 02 years 11 months
Identifying neuroprotective mechanisms against genomic instability accrual in ageing and neurodegeneration
Contracted centre: University of Cambridge
Status: Active
Duration: 00 years 00 months
Identifying novel strategies to restore the microglial homeostatic phenotype and modulate neuroinflammation in dementia
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Identifying the role of neuroinflammation in frontotemporal dementia – a pathological and cerebrospinal fluid biomarker study
Contracted centre: University College London
Status: Active
Duration: 02 years 11 months
Imaging cerebral neuroinflammation in acute and chronic cerebrovascular disease: a predictor of outcome and biomarker for guiding treatment
Contracted centre: The University of Manchester
Status: Completed
Duration: 03 years 11 months
Immune mechanisms of synaptic function and pathology
Contracted centre: University College London
Status: Active
Duration: 00 years 00 months
Improving Diagnosis And Measurement Of Progression In Dementia: Longitudinal Clinical And MRI Studies
Contracted centre: University College London
Status: Completed
Duration: 05 years 04 months
Improving our understanding of vascular mild cognitive impairment and vascular dementia
Contracted centre: Swansea University
Status: Active
Duration: 00 years 00 months
Infections and brain health in ageing populations
Contracted centre: London School of Hygiene & Tropical Medicine
Status: Active
Duration: 07 years 11 months
Inflammatory drivers of long-term comorbidity trajectories: an AI investigation of mulitimorbidity
Contracted centre: University of East Anglia
Status: Completed
Duration: 00 years 11 months
Integrating and storing visuo-spatial cues in the retrosplenial cortex
Contracted centre: Cardiff University
Status: Completed
Duration: 03 years 07 months
Integrating and storing visuo-spatial cues in the retrosplenial cortex
Contracted centre: Cardiff University
Status: Active
Duration: 03 years 07 months
Integration of cell-cell interactions and cell division by novel Dkk1 functions
Contracted centre: King's College London
Status: Active
Duration: 02 years 11 months
Interaction of Rab8 with OCRL1: Synaptic growth function in Frontotemporal Dementia and the Neurodevelopmental Disorder Lowe Syndrome
Contracted centre: University of York
Status: Active
Duration: 02 years 11 months
Interrupting complement interactions to reduce inflammation in neurodegenerative disease
Contracted centre: University College London
Status: Active
Duration: 02 years 11 months
Investigating a potential target for treatment of frontotemporal dementia
Contracted centre: Institute of Psychiatry, King's College London
Status: Active
Duration: 00 years 00 months
Investigating heparins as a potential new drug for Alzheimer’s disease
Contracted centre: University of Liverpool
Status: Active
Duration: 00 years 00 months
Investigating how to clear toxic amyloid protein from the brain in Alzheimer’s disease
Contracted centre: University of Bath
Status: Active
Duration: 00 years 00 months
Investigating nervous system stability using a gene-edited ovine model of dementia
Contracted centre: University of Edinburgh
Status: Active
Duration: 02 years 11 months
Investigating relationships between genes, pathologies, and neurodegeneration in dementia
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Investigating the cellular reaction to amyloid beta and Tau
Contracted centre: University College London
Status: Active
Duration: 00 years 00 months
Investigating the mechanisms of altered cortical excitability in frontotemporal dementia and amyotrophic lateral sclerosis
Contracted centre: King's College London
Status: Active
Duration: 02 years 11 months
Investigating the role of membrane interactions in the aggregation and toxicity of amyloidogenic proteins affecting the heart and vasculature
Contracted centre: Lancaster University
Status: Completed
Duration: 02 years 00 months
Investigating the role of tau in dementia using patient-derived cell models: distinct mechanisms or common endpoint?
Contracted centre: University College London
Status: Completed
Duration: 03 years 11 months
Investigating the thermal biology of inflammasomes – is NLRP3 a thermosensor?
Contracted centre: Queen's University of Belfast
Status: Active
Duration: 02 years 11 months
Is blood-brain barrier dysfunction in Alzheimer’s disease driven by altered cellular metabolism?
Contracted centre: University of Dundee
Status: Active
Duration: 02 years 11 months
JPND LOss of neurotrophic factors in neurodegenerative DEmentias: Back to the crossroads of proteins
Contracted centre: University of Cambridge
Status: Active
Duration: 02 years 11 months
JPND The locus coeruleus: at the crossroad of dementia syndromes
Contracted centre: King's College London
Status: Active
Duration: 02 years 11 months
JPND: BRain Imaging, cognition, Dementia and next generation GEnomics
Contracted centre: University of Edinburgh
Status: Active
Duration: 02 years 11 months
Life course aetiology of dementia and cognitive decline: improving causal inference
Contracted centre: University of Bristol
Status: Active
Duration: 02 years 11 months
Linking genetic, epidemiology and metabolic phenotyping in dementia in the context of aging, environment and lifestyle
Contracted centre: Imperial College London
Status: Active
Duration: 00 years 00 months
Linking the lipid-sensing TMEM16A channel with lysosomal lipid storage mechanisms: implications for drug discovery
Contracted centre: University of Oxford
Status: Active
Duration: 02 years 11 months
Local interactions between tau and synapses in dementia
Contracted centre: University of Bristol
Status: Completed
Duration: 00 years 01 months
Long term memory testing to predict the presence of Alzheimer’s disease pathology
Contracted centre: University of Bristol
Status: Active
Duration: 00 years 00 months
Mapping age-related dysregulation of in vivo synaptic plasticity to molecular synaptic diversity
Contracted centre: Imperial College London
Status: Active
Duration: 02 years 11 months
Mapping and characterising constitutive secretion in human neurons
Contracted centre: University of Cambridge
Status: Active
Duration: 02 years 11 months
Mechanism and design of a pH sensor at the organelle-cytoskeleton interface
Contracted centre: University of Bristol
Status: Active
Duration: 02 years 11 months
Mechanisms and machinery mediating AMPA receptor anchoring in synaptic plasticity
Contracted centre: MRC Laboratory of Molecular Biology
Status: Active
Duration: 02 years 11 months
Mechanisms and machinery mediating AMPA receptor anchoring in synaptic plasticity
Contracted centre: MRC Laboratory of Molecular Biology
Status: Completed
Duration: 02 years 11 months
Mechanisms of Alzheimer’s disease development in Down syndrome
Contracted centre: University College London
Status: Active
Duration: 00 years 00 months
Mechanisms of kinesin control by kinesin binding protein
Contracted centre: King's College London
Status: Active
Duration: 03 years 01 months
Mechanisms of neuronal loss in dementia: Role of matrix metalloproteinases in the degradation of the perineuronal net
Contracted centre: University of Bradford
Status: Completed
Duration: 03 years 02 months
Mechanistic insight into a novel TIF-IA-NF-kB nucleolar stress response pathway and elucidation of its role in senescence
Contracted centre: University of Edinburgh
Status: Completed
Duration: 03 years 04 months
Memory dynamics: the cellular architecture of systems memory
Contracted centre: University of Bristol
Status: Active
Duration: 04 years 04 months
Memory formation in the human medial temporal lobe
Contracted centre: University of Leicester
Status: Active
Duration: 02 years 11 months
Metabolic control of amyloid formation and synapse loss in dementia (Molecular amyloidosis & synaptopathy)
Contracted centre: UK Dementia Research Institute at King’s College London
Status: Active
Duration: 04 years 11 months
Micro-circuit homeostasis in early Alzheimer’s disease
Contracted centre: Imperial College London
Status: Active
Duration: 00 years 00 months
Microglial mechanisms influencing susceptibility and resilience to dementia-causing disease
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Mining a common food compound, Epicatechin, for a new Alzheimer’s disease treatment
Contracted centre: University of Bath
Status: Completed
Duration: 02 years 10 months
Modelling dementia progression based on machine learning and simulations
Contracted centre: Newcastle University
Status: Active
Duration: 02 years 11 months
Multi-modal machine learning of large-scale genetic, biologic, and brain imaging data for identification of therapeutic targets and early prediction
Contracted centre: Imperial College London
Status: Active
Duration: 03 years 11 months
Multimodal neuroimaging analysis to investigate structural brain connections implicated in development of neurodegeneration, cognitive impairment, and
Contracted centre: Imperial College London
Status: Active
Duration: 03 years 05 months
Multiscale and multimodal brain network changes causing Parkinson’s dementia
Contracted centre: University College London
Status: Active
Duration: 07 years 11 months
Muscle resilience across the life course: from cells to society
Contracted centre: University of Southampton
Status: Active
Duration: 01 years 11 months
Myeloid cells in neurodegenerative diseases
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Neural system failure in dementia
Contracted centre: UK Dementia Research Institute at University College London
Status: Active
Duration: 04 years 11 months
Neuro-vascular mechanisms of direct oral anticoagulant therapy in younger patients with atrial fibrillation: the DaRe2THINK-NV sub-study
Contracted centre: University of Birmingham
Status: Active
Duration: 03 years 11 months
Non-cell autonomous mechanisms of synapse pathology
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Non-invasive MRI of blood-cerebrospinal fluid barrier function: addressing a critical failure in the middle aged brain
Contracted centre: University College London
Status: Active
Duration: 07 years 11 months
On TReND: Mild Traumatic Brain Injury and the Contentious Reimagining of Alzheimer Disease-Related Dementias as Environmental Diseases
Contracted centre: University of Sheffield
Status: Completed
Duration: 04 years 11 months
Optimising Neuroimaging Biomarkers for Dementia Using Deep Learning
Contracted centre: University College London
Status: Active
Duration: 03 years 11 months
Oral health and Alzheimer’s disease
Contracted centre: University of Bristol
Status: Active
Duration: 00 years 00 months
Predicting neurodegeneration after traumatic brain injury: a longtitudinal study of enviormental risk factor for Alzheimer’s disease
Contracted centre: Imperial College London
Status: Completed
Duration: 02 years 11 months
Predicting the risk of dementia using routine primary health care records
Contracted centre: University of Manchester
Status: Completed
Duration: 01 years 11 months
Profiling dementias using complex sound: from symptoms to brain networks.
Contracted centre: University College London
Status: Completed
Duration: 06 years 04 months
PROMED-COG: PROtein enriched MEDiterranean diet to combat undernutrition and promote healthy neuroCOGnitive ageing in older adults
Contracted centre: Queen's University of Belfast
Status: Active
Duration: 02 years 05 months
Protein interactions and mitochondrial dynamics in dementia with Lewy bodies
Contracted centre: Plymouth University
Status: Active
Duration: 00 years 00 months
Proteostatic mechanisms in FTD and ALS
Contracted centre: King's College London
Status: Active
Duration: 00 years 00 months
Real-time interrogation of neural circuit dynamics underpinning cognition and its collapse in dementia
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Redefining the mechanisms that promote healthy ageing downstream of HSF1
Contracted centre: University College London
Status: Active
Duration: 02 years 11 months
Reducing age-related axon loss
Contracted centre: Babraham Institute
Status: Completed
Duration: 03 years 11 months
Regulation and activities of amyloidogenic proteins APP and TGFBI in physiological and pathological protein aggregation
Contracted centre: University of Oxford
Status: Active
Duration: 02 years 11 months
Regulation of astroglial branch morphogenesis during visual circuit assembly in Drosophila
Contracted centre: The Francis Crick Institute
Status: Completed
Duration: 03 years 11 months
Regulation of inhibitory synapse function by Neuroligin 2 membrane dynamics, trafficking and phosphorylation
Contracted centre: University College London
Status: Completed
Duration: 03 years 11 months
Regulation of neurotransmitter synthesis in Alzheimer’s disease – potential for dietary supplements to improve cognition
Contracted centre: University of the West of England
Status: Active
Duration: 00 years 00 months
Regulation of plateau potentials by dendritically targeted inhibitory synaptic transmission.
Contracted centre: University of Bristol
Status: Active
Duration: 02 years 11 months
Rescuing neurotrophic signalling through Rab10: a novel therapeutic target for Alzheimer’s disease.
Contracted centre: University College London
Status: Active
Duration: 02 years 11 months
Restoring axonal transport deficits as a therapeutic strategy for neurodegenerative diseases
Contracted centre: University College London
Status: Active
Duration: 00 years 00 months
Restoring brain function: from cortical microcircuits to complex behaviours in neurodegenerative disease
Contracted centre: University of Cambridge
Status: Completed
Duration: 06 years 05 months
Role of ER dynamics and morphological regulation in neuronal health and disease
Contracted centre: University of Cambridge
Status: Active
Duration: 00 years 00 months
Role of IFNGR1 in reactive astrocyte activation
Contracted centre: University of Edinburgh
Status: Active
Duration: 03 years 08 months
Role of kinesin light chain 1 in binding to specific cargoes.
Contracted centre: The University of Manchester
Status: Active
Duration: 02 years 11 months
Role of LAP in controlling liver homeostasis
Contracted centre: Quadram Institute Bioscience
Status: Active
Duration: 02 years 11 months
Role of ubiquitin protein ligase Nedd4.1 and Nedd4.2 in dementia with Lewy bodies
Contracted centre: Plymouth University
Status: Active
Duration: 00 years 00 months
Roles of post-translational modifications in neurodegenerative protein aggregation
Contracted centre: Imperial College London
Status: Active
Duration: 02 years 11 months
Roles of protein SUMOylation in AMPA receptor trafficking, synaptic dysfunction and cognitive impairment in dementia
Contracted centre: University of Bristol
Status: Active
Duration: 03 years 11 months
Second Joint Stroke Association/BHF Programme Grant – How intensively should we treat blood pressure in established cerebral small vessel disease?
Contracted centre: University of Cambridge
Status: Completed
Duration: 05 years 00 months
Sex Peptide-dependent microcarrier signalling in reproduction
Contracted centre: University of Oxford
Status: Active
Duration: 02 years 11 months
Simple questions about neurodegenerative disease: where? when? how?
Contracted centre: Imperial College London
Status: Active
Duration: 00 years 00 months
Single molecule nucleocytoplasmic transport dynamics in FTD/ALS
Contracted centre: King's College London
Status: Active
Duration: 00 years 00 months
Small vessel disease and vascular contributions to neurodegeneration and dementia
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
Small vessel diseases and vascular contributions to neurodegeneration and dementia
Contracted centre: UK Dementia Research Institute at University of Edinburgh
Status: Active
Duration: 83 years 03 months
STAR | Start Healthy – Stay Healthy | Aligning Public and Planetary Health Through Precision Plant-Based Dietary Solutions across the Life-course
Contracted centre: University of Surrey
Status: Active
Duration: 04 years 11 months
Striking the right balance – WNT signalling in Alzheimer’s disease.
Contracted centre: University of Exeter
Status: Active
Duration: 00 years 00 months
Structural and functional investigation of the SRSF1-mediated nuclear export of mRNAs
Contracted centre: University of Leicester
Status: Completed
Duration: 03 years 07 months
Structural and pathological consequences of aSyn/lipid membrane interactions
Contracted centre: Imperial College London
Status: Active
Duration: 03 years 11 months
Structure-function relationship in neurodegeneration
Contracted centre: University College London
Status: Active
Duration: 00 years 00 months
Synapse weakening in the pathophysiology of Alzheimer’s disease
Contracted centre: King's College London
Status: Active
Duration: 00 years 00 months
Synaptic repair mechanisms for the diseased brain
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
SynBioSphinx: building designer lipid membranes for adaptive resilience to environmental challenges.
Contracted centre: University of Edinburgh
Status: Active
Duration: 03 years 10 months
Systems-based machine learning approach to understanding clinical, genetic, and pathophysiological heterogeneity in Parkinson’s dementia
Contracted centre: University College London
Status: Active
Duration: 04 years 00 months
Taking an innovative approach to designing potential treatments for Alzheimer’s disease
Contracted centre: University of Cambridge
Status: Active
Duration: 00 years 00 months
Taking the long view: Identification of plasma protein biomarkers for dementia risk
Contracted centre: University College London
Status: Active
Duration: 04 years 11 months
Targeting novel anti-complement drugs to the brain for therapy of dementia.
Contracted centre: University of Cardiff
Status: Active
Duration: 00 years 00 months
Targeting TDP-43 meditated neurodegeneration for therapitic benefit in dementia
Contracted centre: King's Collefe London, Institute of Psychiatry, Psychology & Neuroscience
Status: Active
Duration: 02 years 11 months
The AlzEye Study – Using the Eye as a Window to Systemic Health
Contracted centre: University College London
Status: Active
Duration: 03 years 11 months
The chaperone cycle of fibroblast growth factor receptor kinases in molecular detail
Contracted centre: University of Leeds
Status: Active
Duration: 02 years 11 months
The chaperone cycle of fibroblast growth factor receptor kinases in molecular detail
Contracted centre: University of Leeds
Status: Active
Duration: 02 years 11 months
The GENetic Frontotemporal Dementia Initiative (GENFI): a new multi-centre platform for the study of frontotemporal lobar degeneration
Contracted centre: University College London
Status: Completed
Duration: 01 years 11 months
The influence of fragrances on brain activity and brain health
Contracted centre: University College London
Status: Active
Duration: 03 years 11 months
The microfluidic ion pump: a new tool for understanding the brain
Contracted centre: University of Cambridge
Status: Active
Duration: 04 years 11 months
The molecular causes and consequences of tauopathy in Alzheimer’s disease and Frontotemporal dementia
Contracted centre: University College London
Status: Active
Duration: 00 years 00 months
The NET-PDD study: defining the roles of NEuroinflammation and Tau aggregation in Parkinson’s Disease Dementia
Contracted centre: University of Cambridge
Status: Active
Duration: 04 years 11 months
The pathways to prion formation in the response to oxidative stress
Contracted centre: The University of Manchester
Status: Completed
Duration: 03 years 08 months
The pathways to prion formation in the response to oxidative stress
Contracted centre: The University of Manchester
Status: Completed
Duration: 03 years 08 months
The relationship between later life depression and Alzheimer’s disease: bystander or participant?
Contracted centre: University of Bristol
Status: Active
Duration: 00 years 00 months
The role of B lymphocytes in the development of Parkinson’s disease and its associated dementia.
Contracted centre: University of Cambridge
Status: Completed
Duration: 03 years 03 months
The role of capillary pericytes and LRP-1 in Parkinson’s disease and dementia
Contracted centre: University College London
Status: Active
Duration: 03 years 11 months
The Role of Extracellular Vesicles in Post-Stroke Vascular Dysfunction
Contracted centre: University of Oxford
Status: Active
Duration: 02 years 11 months
The role of glia and the cerebral vasculature in dementia
Contracted centre: University College London
Status: Active
Duration: 05 years 00 months
The role of inherited and acquired mitochondrial DNA mutations in Dementia with Lewy Bodies.
Contracted centre: Newcastle University
Status: Completed
Duration: 01 years 04 months
The role of perturbed nitric oxide signalling in disruption of the neurovascular unit of the blood brain barrier by environmental and genetic risk factors for Alzheimer’s disease
Contracted centre: Imperial College London
Status: Completed
Duration: 03 years 00 months
The role of sleep in protecting against amyloid and glial pathology in dementia
Contracted centre: UK Dementia Research Institute at Imperial College London
Status: Active
Duration: 83 years 03 months
The role of tau in synapse survival and its relevance to Alzheimer’s disease
Contracted centre: University of Edinburgh
Status: Active
Duration: 04 years 11 months
The role of tau in synapse survival and its relevance to Alzheimer’s disease
Contracted centre: University of Edinburgh
Status: Active
Duration: 00 years 00 months
The subiculum: a key interface between scene representation and event memory?
Contracted centre: Cardiff University
Status: Active
Duration: 02 years 11 months
The subiculum: a key interface between scene representation and event memory?
Contracted centre: Royal Holloway, Univ of London
Status: Active
Duration: 02 years 11 months
The suprastructure-function relationship between amyloid assemblies and their toxic and infectious potentials
Contracted centre: University of Sussex
Status: Completed
Duration: 04 years 01 months
The suprastructure-function relationship between amyloid assemblies and their toxic and infectious potentials
Contracted centre: University of Sussex
Status: Completed
Duration: 04 years 01 months
The systemic approach on the investigation of the association of cardiometabolic risk factors and dementia
Contracted centre: Imperial College London
Status: Active
Duration: 04 years 08 months
The UK GENetic Frontotemporal dementia Initiative
Contracted centre: University College London
Status: Active
Duration: 04 years 11 months
To mate or to flee: neural mechanisms underlying action-selection
Contracted centre: University of Birmingham
Status: Completed
Duration: 03 years 08 months
Toll and kinase-less Trk receptors in concert drive a novel mechanism of structural synaptic plasticity.
Contracted centre: University of Birmingham
Status: Completed
Duration: 03 years 11 months
Towards an in vivo functional dissection of the role of microglia and macrophages in Alzheimer’s disease aetiology
Contracted centre: University of Cardiff
Status: Active
Duration: 00 years 00 months
Transcriptional profiling of nutritional deficiency in single neurons: insights for state-dependent behaviour and healthy ageing
Contracted centre: Durham University
Status: Active
Duration: 02 years 11 months
Translating brain magnetic resonance imaging signals to iron and myelin to appraise Alzheimer’s disease
Contracted centre: King's College London
Status: Active
Duration: 03 years 11 months
Understanding Amyloid Post-Translational Modification at the Nanoscale
Contracted centre: Imperial College London
Status: Active
Duration: 03 years 11 months
Understanding and repairing pathological neural circuits in Alzheimer’s disease
Contracted centre: University College London
Status: Active
Duration: 00 years 00 months
Understanding cell type gene regulation in ageing-related brain disorders
Contracted centre: Imperial College London
Status: Active
Duration: 00 years 00 months
Understanding developmentally controlled co-transcriptional splicing in the mammalian nervous system
Contracted centre: King's College London
Status: Active
Duration: 02 years 11 months
Understanding Infection in People with Dementia: Incidence, Impact and Prevention.
Contracted centre: University of Cambridge
Status: Completed
Duration: 07 years 03 months
Understanding Infection in People with Dementia: Incidence, Impact and Prevention.
Contracted centre: Univeristy of Cambridge
Status: Active
Duration: 07 years 03 months
Understanding the Contributions of Multiple Pathologies to Dementia in the BDR Programme
Contracted centre: Univsersity of Newcastle
Status: Completed
Duration: 03 years 00 months
Understanding the Contributions of Multiple Pathologies to Dementia in the BDR Programme
Contracted centre: University of Newcastle
Status: Completed
Duration: 03 years 00 months
Understanding the effects of the diabetes type 2 drug Metformin on models of Alzheimer’s disease
Contracted centre: University College London
Status: Active
Duration: 03 years 00 months
Understanding the links between psychological wellbeing and cognitive decline and dementia
Contracted centre: University College London
Status: Active
Duration: 02 years 11 months
Understanding the molecular basis of tau aggregation and spreading
Contracted centre: University of Cambridge
Status: Active
Duration: 00 years 00 months
Understanding the molecular mechanisms of endocytic genes and polygenic risk in late onset Alzheimer’s disease
Contracted centre: University of Cardiff
Status: Active
Duration: 00 years 00 months
Understanding the role of hair cell mechanoelectrical transduction in age-related and noise-induced hearing loss
Contracted centre: University of Sheffield
Status: Active
Duration: 02 years 11 months
Understanding the role of neurodegenerative disease risk genes in the ageing nervous system
Contracted centre: University of Cardiff
Status: Active
Duration: 00 years 00 months
Understanding the roles of SUMO proteases in neuronal function and viability
Contracted centre: University of Bristol
Status: Active
Duration: 05 years 04 months
Understanding whether drugs for rheumatoid arthritis can reduce the risk of Alzheimer’s disease
Contracted centre: Queen's University Belfast
Status: Active
Duration: 00 years 00 months
Unravelling cellular sensing pathways that contribute to Alzheimer’s disease pathology
Contracted centre: University of the West of England
Status: Active
Duration: 00 years 00 months
Unravelling the molecular basis of the association of genetic variation in the clusterin gene with risk of Alzheimer’s disease
Contracted centre: Cardiff University School of Medicine
Status: Active
Duration: 02 years 11 months
Untangling toxic aggregates in neurodegeneration with the ubiquitin-proteasome system
Contracted centre: Imperial College London
Status: Active
Duration: 00 years 00 months
Using genetics to explore the pathophysiology of cerebral small vessel disease
Contracted centre: University of Cambridge
Status: Completed
Duration: 05 years 00 months
Using genetics to identify dementia risk factors.
Contracted centre: University of Bristol
Status: Active
Duration: 00 years 00 months
Using graph networks to identify microbiome-based therapeutics for neurodegenerative diseases
Contracted centre: University College London
Status: Active
Duration: 04 years 00 months
Using stem cells to discover how calorie restriction could protect against dementia
Contracted centre: Swansea University
Status: Active
Duration: 00 years 00 months
Using stem cells to model protein quality control dysfunction in dementia
Contracted centre: Cardiff University
Status: Active
Duration: 00 years 00 months
Using visual dysfunction to understand dementia in Parkinson’s disease
Contracted centre: University College London
Status: Active
Duration: 06 years 03 months
Vascular dementia: failure of fluid drainage from cerebral white matter (Joint funding with Stroke Association and Alzheimer’s Society for Advancing Care and Treatment of Vascular Dementia (ACT-VAD))
Contracted centre: University of Southampton
Status: Completed
Duration: 03 years 00 months
Vector Trace cells in the Subiculum of the hippocampal formation
Contracted centre: Durham University
Status: Completed
Duration: 02 years 05 months
Vector Trace cells in the Subiculum of the hippocampal formation
Contracted centre: Durham University
Status: Active
Duration: 02 years 05 months
Water exchange in the vasculature of the brain (WEX-BRAIN)
Contracted centre: Lancaster University
Status: Active
Duration: 02 years 11 months
What does the human face tell the human brain?
Contracted centre: University College London
Status: Active
Duration: 04 years 03 months
What role do different interneurons in medial prefrontal cortex play in associative recognition memory?
Contracted centre: University of Bristol
Status: Active
Duration: 02 years 11 months
Why do mitochondria produce more ROS when we age?
Contracted centre: University of Glasgow
Status: Active
Duration: 02 years 11 months
Α-synuclein and cellular iron reduction
Contracted centre: University of Bath
Status: Completed
Duration: 00 years 00 months
Α-synuclein expression regulates the breakdown of amyloid precursor protein
Contracted centre: University of Bath
Status: Completed
Duration: 00 years 00 months