Reducing age-related axon loss

Award Number
Status / Stage
1 October 2013 -
30 September 2017
Duration (calculated)
03 years 11 months
Funding Amount
Funder/Grant study page
Contracted Centre
Babraham Institute
Principal Investigator
Mr Merve Elman
WHO Catergories
Understanding Underlying Disease
Disease Type
Dementia (Unspecified)

CPEC Review Info
Reference ID700
ResearcherReside Team


Award NumberBBS/E/B/000L0784
Status / StageCompleted
Start Date20131001
End Date20170930
Duration (calculated) 03 years 11 months
Funder/Grant study pageBBSRC UKRI
Contracted CentreBabraham Institute
Funding Amount£10,548.00


Age-related axon loss is a major contributor to cognitive decline and physical frailty during normal ageing. We lose 45% of the white matter in our brain by age 80 and 40% of our skin innervation by 60. Similar processes can be modelled in mice, which lose around 30% of tibial nerve axons and axonal arbors of retinal ganglion cells by 24 months. Age-related axon loss also reduces the scope for compensatory responses to neurodegenerative disease. Thus, even though mechanisms of age-related axon loss and disease may differ, this aspect of normal ageing is likely to accelerate symptom onset and underlie the fact that ageing is the biggest single risk factor for Alzheimer’s disease, Parkinson’s disease, motor neuron disease and other disorders.