Understanding Infection in People with Dementia: Incidence, Impact and Prevention.
Award TypeDoctoral Research Fellowship
Status / StageActive
Dates2 September 2015 -
31 December 2022
Duration (calculated)07 years 03 months
Funder/Grant study pageNIHR
Contracted CentreUniveristy of Cambridge
Principal InvestigatorDr Angelique Mavrodaris
WHO CatergoriesHigh quality epidemiological data
Risk reduction intervention
Understanding Underlying Disease
Disease TypeDementia (Unspecified)
CPEC Review Info
|Status / Stage
|07 years 03 months
|Funder/Grant study page
|Univeristy of Cambridge
As populations worldwide are ageing, the prevalence of dementia is increasing rapidly. Patients with dementia are at higher risk of infection. Infection may be a modifiable determinant of dementia outcomes. I aim to quantify the incidence of infection among people with dementia in the community and to determine the association of dementia with important outcomes in this population. The study encompasses four phases: 1. A systematic review of studies determining the association between infection and outcomes in dementia. 2. Analysis of primary care data from the Clinical Practice Research Datalink (CPRD) to measure the incidence of infections and subgroups at increased risk of infection, among people with dementia. 3. Analysis of patients accessing secondary mental health care within the South London and Maudsley NHS Foundation Trust from the Case Register Interactive Search (CRIS) system to quantify the association of infection with mortality, cognitive (Mini-Mental State Examination) and functional outcomes (Health of the Nation Outcomes Scale) among people with dementia. 4. Findings will be used to develop a public health intervention aimed at prevention and early management of infection among people with dementia. Research Question To what extent do common infections contribute to disease progression in older people with dementia and can this contribution be prevented? Research Aims To quantify the incidence of significant infection among people with dementia and to determine the association of infection with important outcomes in dementia. Objectives 1. To quantify the incidence of infection in people with dementia and the most common infections present. 2. To identify subgroups of older people with dementia who are at increased risk of infection. 3. To quantify the impact and physical, cognitive and functional outcomes associated with infection in people with dementia. 4. To assess whether an intervention aimed at prevention and early management of infection among people with dementia can be designed for evaluation as part of a complex intervention trial.
People with dementia are more likely to be admitted to hospital with infections, after which they often deteriorate. Infection may be an important target for public health interventions as infections are potentially preventable. I will analyse two large datasets that collect records from GPs, mental health services, and hospital admissions. This will allow me to establish what the added risk of infection is, which infections and which patients are at highest risk, and whether infections are associated with worse health outcomes, in people with dementia. Using these outputs, I will develop an intervention to reduce infection among people with dementia.