Investigating how to clear toxic amyloid protein from the brain in Alzheimer’s disease

Award Type
PhD studentship
Status / Stage
Alzheimer's Society
Funding Amount
Funder/Grant study page
Alzheimer's Society
Contracted Centre
University of Bath
Principal Investigator
Professor K. Ravi Acharya
PI Contact
WHO Catergories
Understanding Underlying Disease
Disease Type
Alzheimer's Disease (AD)

CPEC Review Info
Reference ID41
ResearcherReside Team


Status / StageActive
Funder/Grant study pageAlzheimer's Society
Contracted CentreUniversity of Bath
Funding Amount£84,900.00


Alzheimer’s disease is characterised by build ups or plaques of a toxic protein called amyloid beta, which causes the brain cells to get sick and die.
This project will investigate a special protein or enzyme called neprilysin to understand how it breaks down amyloid beta protein in the healthy brain. There is a well-established link between amyloid beta accumulation and the progression of Alzheimer’s disease. One strategy for designing new treatments for Alzheimer’s disease is developing drugs that target amyloid beta and cause it to be broken down.
By investigating how the enzyme neprilysin breaks down amyloid beta protein, this research study could lead discover a new drug target to reduce amyloid beta levels in the brain. It is hoped that by reducing amyloid beta protein build ups, treatments may be able to slow down the progression of Alzheimer’s disease.

Understanding how to target parts of the brain cell that break down amyloid beta is one strategy researchers can use to develop new treatments for Alzheimer’s disease.


This project will build on our understanding of one of these enzymes, known as neprilysin. Professor Acharya and his team will use several biochemistry and molecular laboratory techniques to gain an in-depth understanding of how the neprilysin enzyme breaks down amyloid beta.

The researchers will also produce altered forms of the enzyme, with the aim of identifying a form which degrades amyloid beta more efficiently.