Vascular dementia: failure of fluid drainage from cerebral white matter (Joint funding with Stroke Association and Alzheimer’s Society for Advancing Care and Treatment of Vascular Dementia (ACT-VAD))

Award Number
Award Type
Chairs & Programme Grants
Status / Stage
1 September 2017 -
1 September 2020
Duration (calculated)
03 years 00 months
British Heart Foundation (BHF)
Funding Amount
Funder/Grant study page
British Heart Foundation
Contracted Centre
University of Southampton
Principal Investigator
Professor Roxana Carare
WHO Catergories
Understanding risk factors
Understanding Underlying Disease
Disease Type
Vascular Dementia (VD)

CPEC Review Info
Reference ID589
ResearcherReside Team


Award NumberSP/17/6/33092
Status / StageCompleted
Start Date20170901
End Date20200901
Duration (calculated) 03 years 00 months
Funder/Grant study pageBritish Heart Foundation
Contracted CentreUniversity of Southampton
Funding Amount£111,810.00

Plain English Summary

Dr Roxana Carare from the University of Southampton is studying vascular dementia, a common form of dementia where the brain’s blood supply is impaired. She believes vascular dementia happens because the brain cannot get rid of waste and fluid properly. The brain removes its waste along extremely thin pathways embedded in the walls of narrow blood vessels. Dr Carare believes vascular dementia occurs in part because these pathways are not correctly anchored to the blood vessel wall. This means that water channels do not work correctly and waste cannot be eliminated properly from the brain. In this project, jointly funded by the BHF, the Stroke Association and Alzheimer’s Society, Dr Carare will study how this ‘anchoring’ affects water transport and the brain. She will study waste elimination in mice with disrupted anchoring, and compare these mouse brains with human brains with vascular dementia. She will also analyse mouse brains with disrupted channels for water exchange. This research could lead to targeted treatments for vascular dementia that work by draining waste fluid from the brain.