Systematic reviews of interventions which target modifiable risk factors for dementia

Award Number
Evidence Synthesis Programme
Status / Stage
2 June 2014 -
30 November 2016
Duration (calculated)
02 years 05 months
Funding Amount
Funder/Grant study page
Contracted Centre
University of Oxford
Principal Investigator
Dr Rupert McShane
PI Contact
WHO Catergories
Risk reduction intervention
Understanding risk factors
Disease Type
Dementia (Unspecified)

CPEC Review Info
Reference ID84
ResearcherReside Team


Award Number13/89/22
Status / StageCompleted
Start Date20140602
End Date20161130
Duration (calculated) 02 years 05 months
Funder/Grant study pageNIHR
Contracted CentreUniversity of Oxford
Funding Amount£278,199.58


The last 200 years have seen a hugely successful effort by the world’s economies to change the main risk factor for dementia: the age at which we die. Unfortunately, this has been in the wrong direction and one in three of us now die suffering from dementia. The societal costs are huge. Less pessimistically, the age-specific prevalence of dementia has recently been shown to have declined in the UK from 8.3% to 6.5% of those over 65 years over the last 20 years. This substantial change, shown by the robust MRC Cognitive Function and Ageing Study, suggests that there may be risk factors which can be modified. Obvious candidates include diet, education and vascular risk factors (blood pressure, smoking, cholesterol, diabetes and exercise). Some risk factors may be more dementia-specific, averting or slowing symptom progression in prodromal disease. We all have a personal stake in knowing whether interventions which alter these putative risks will reduce our chances of dementia.