Muscle resilience across the life course: from cells to society
Award Number
BB/W018284/1Status / Stage
ActiveDates
1 February 2022 -31 January 2024
Duration (calculated)
01 years 11 monthsFunder(s)
BBSRC (UKRI)Funding Amount
£184,485.00Funder/Grant study page
BBSRC UKRIContracted Centre
University of SouthamptonPrincipal Investigator
Professor Peter SmithPI Contact
pete.smith@abdn.ac.ukPI ORCID
0000-0003-0319-718XWHO Catergories
Understanding Underlying DiseaseDisease Type
Dementia (Unspecified)CPEC Review Info
| Reference ID | 694 |
|---|---|
| Researcher | Reside Team |
| Published | 07/07/2023 |
Data
| Award Number | BB/W018284/1 |
|---|---|
| Status / Stage | Active |
| Start Date | 20220201 |
| End Date | 20240131 |
| Duration (calculated) | 01 years 11 months |
| Funder/Grant study page | BBSRC UKRI |
| Contracted Centre | University of Southampton |
| Funding Amount | £184,485.00 |
Abstract
A prominent change associated with ageing is the loss of muscle mass and function. As muscle is critical for physical function and metabolic homeostasis, loss of muscle mass and function results in adverse outcomes and is the major cause of loss of independence in old age. Muscle ageing is characterised by a variety of molecular, physiological, and systemic changes, often overlapping and interdependent. Ageing related changes in muscle are not linear or consistent and there is considerable variation across aged populations. Some of the variability can be explained by fixed genetic factors, but much of the variation is due to an individual’s physical and social environment, with factors such as physical activity, nutrition, and socio-economic background all playing a role. Although research has focused on understanding the determinants of muscle ageing, the complexity of the process requires a new, convergent approach. We need to move away from systems in isolation towards a holistic understanding of muscle ageing where molecular, physiological, organism and population level research is combined. The MyAge network will break down the silos associated with reductionist research, bringing together non-overlapping expertise, researchers, industrialists, and stakeholders, from musculoskeletal research, metabolism, regenerative medicine, ‘omics, epigenetics, maths, data and social sciences, health inequity, biotech, and pharma, to understand the mechanistic pathways of muscle development, differentiation and decline. The MyAge network will: Create a national, interdisciplinary network in muscle resilience with international links identifying big questions and developing novel hypotheses Through secondments deliver training opportunities for next generation researchers and technicians. Develop a roadmap for muscle ageing research to inform policy development, targeting proactive steps to address muscle ageing and related health inequities and inequalities.
Aims
The aim of this network is to bring together researchers, businesses and the people and organisations that benefit from research, from many areas, offering new insights into muscle health and an understanding of the pathways leading to muscle ageing