Plain English Summary

Professor David Middleton and his colleagues at Lancaster University are studying how proteins called amyloid build up in the heart and circulatory system, having potentially devastating effects on health. In several diseases, proteins clump together to form deposits called amyloid that builds up in organs. In Alzheimer’s disease, amyloid plaques accumulate in the brain. Amyloid protein can also affect the heart and circulatory system – it is deposited in the arteries of virtually everyone over the age of 50, and scientists think this increases the risk of aneurysms (bulging of the blood vessels) in older people. Scientists have discovered that the amyloid protein found in Alzheimer’s disease interacts with the outside layer of brain cells, causing the protein to clump together more quickly and then damage the cells. In this project, Professor Middleton’s team will study two proteins that form amyloid in the heart and blood vessels, and investigate whether they too interact with the outer layers of cells and clump together to form amyloid, destroying cells and affecting the heart and blood vessels. They will also investigate whether these amyloid proteins damage or destroy the cells by making them leaky. This work will help us to understand what causes amyloid diseases that affect the heart and blood vessels and could help eventually develop new treatments.