Dementias Platform UK MR-PET Partnership
Award Number
MR/N025792/1Programme
Research GrantStatus / Stage
ActiveDates
28 September 2016 -27 September 2019
Duration (calculated)
02 years 11 monthsFunder(s)
MRC (UKRI)Funding Amount
£860,793.36Funder/Grant study page
MRC UKRIContracted Centre
The University of ManchesterContracted Centre Webpage
Principal Investigator
Karl HerholzPI ORCID
0000-0002-8658-0151WHO Catergories
Development of BiomarkersTools and methodologies for interventions
Disease Type
Dementia (Unspecified)CPEC Review Info
| Reference ID | 257 |
|---|---|
| Researcher | Reside Team |
| Published | 12/06/2023 |
Data
| Award Number | MR/N025792/1 |
|---|---|
| Status / Stage | Active |
| Start Date | 20160928 |
| End Date | 20190927 |
| Duration (calculated) | 02 years 11 months |
| Funder/Grant study page | MRC UKRI |
| Contracted Centre | The University of Manchester |
| Contracted Centre Webpage | |
| Funding Amount | £860,793.36 |
Abstract
This partnership grant aims at providing coherent and harmonised operations of the DPUK MR-PET network. It will tightly be managed within the DPUK imaging platform, where it relates primarily to the work package on clinical governance which is led by Prof. Karl Herholz. We will also closely cooperate with the DPUK imaging work packages on radiochemistry, data analysis, and IT. This will be ensured by the composition of the executive team, representation of all disciplines in the steering committee, and by overlap between network task force leadership with the broader work package leadership of the DPUK imaging platform. The imaging platform will comprise seven MR-PET scanners from two different vendors. Thus, one obvious priority is minimising differences in image quality and quantification, while still maximising the benefits of MR-PET over separate MR and PET scanning. This will be addressed by investigation into the technical characteristics of the scanning and image reconstruction, but also by providing appropriate cross-training of staff, and by devising harmonised SOPs. Initially we will concentrate on harmonising established MR protocols and tracers, in particular to provide the current standard set of imaging biomarkers for dementia research. We will also facilitate implementation of research studies using other tracers and MR techniques. Four major tasks have been identified to reach these goals. Task force 1 is providing the essential means for effective communication and reporting, task force 2 will organise training, and task force 3 will conduct the harmonisation scanning study. An additional task force (#4) will address governance, regulations and business development to ensure continuous growth of activities for long-term sustainability. Task forces will adhere to a detailed project plan with specific deliverables and annual reporting to the DPUK management board.
Aims
This partnership grant aims at providing coherent and harmonised operations of the DPUK MR-PET network. It will tightly be managed within the DPUK imaging platform, where it relates primarily to the work package on clinical governance which is led by Prof. Karl Herholz. We will also closely cooperate with the DPUK imaging work packages on radiochemistry, data analysis, and IT. This will be ensured by the composition of the executive team, representation of all disciplines in the steering committee, and by overlap between network task force leadership with the broader work package leadership of the DPUK imaging platform.
The imaging platform will comprise seven MR-PET scanners from two different vendors. Thus, one obvious priority is minimising differences in image quality and quantification, while still maximising the benefits of MR-PET over separate MR and PET scanning. This will be addressed by investigation into the technical characteristics of the scanning and image reconstruction, but also by providing appropriate cross-training of staff, and by devising harmonised SOPs. Initially we will concentrate on harmonising established MR protocols and tracers, in particular to provide the current standard set of imaging biomarkers for dementia research. We will also facilitate implementation of research studies using other tracers and MR techniques.
Four major tasks have been identified to reach these goals. Task force 1 is providing the essential means for effective communication and reporting, task force 2 will organise training, and task force 3 will conduct the harmonisation scanning study. An additional task force (#4) will address governance, regulations and business development to ensure continuous growth of activities for long-term sustainability. Task forces will adhere to a detailed project plan with specific deliverables and annual reporting to the DPUK management board.