Cardiovascular mechanisms linked to cerebral amyloid β deposition and cognitive decline: A substudy of INSIGHT 46

Award Number
Project Grant
Status / Stage
1 February 2018 -
1 September 2020
Duration (calculated)
02 years 07 months
British Heart Foundation (BHF)
Funding Amount
Funder/Grant study page
British Heart Foundation
Contracted Centre
University College London
Contracted Centre Webpage
Principal Investigator
Professor Alun Hughes
PI Contact
WHO Catergories
Models of Disease
Understanding Underlying Disease
Disease Type
Dementia (Unspecified)

CPEC Review Info
Reference ID590
ResearcherReside Team


Award NumberPG/17/90/33415
Status / StageCompleted
Start Date20180201
End Date20200901
Duration (calculated) 02 years 07 months
Funder/Grant study pageBritish Heart Foundation
Contracted CentreUniversity College London
Contracted Centre Webpage
Funding Amount£300,471.00

Plain English Summary

The number of people affected by dementia has increased dramatically in recent years. Heart and circulatory diseases are known to be associated with dementia, but the processes underlying this link are poorly understood. It is suspected that low blood flow into the brain may be a contributing factor. In this project, Professor Alun Hughes and his team at UCL will study the relationships between the structures and function of brain and heart and circulatory system. They will follow the progress of 375 people taking part in the MRC National Survey of Health and Development. The participants have all had their brain, blood pressure and heart function monitored throughout their adult life. At age 70 their levels of ß-amyloid, a marker of dementia, were also measured. In this project, Professor Hughes and his team will measure the blood flow in the brain of the participants, now aged 72, to investigate whether heart and circulatory disease can influence mental decline and dementia. The results will increase our understanding of the causes of cognitive decline, whether blood flow to the brain is compromised in people with ß-amyloid, and whether this is linked to cardiovascular health. The results could highlight new pathways for treatments, help find the best time points for the prevention of dementia, and identify those individuals most at risk.