Can leptin, the anti-obesity hormone, protect brain cells?
Award Type
PhD StudentshipStatus / Stage
ActiveFunder(s)
Alzheimer's SocietyFunding Amount
£85,000.00Funder/Grant study page
Alzheimer's SocietyContracted Centre
University of DundeePrincipal Investigator
Dr Jenni HarveyPI Contact
j.z.harvey@dundee.ac.ukWHO Catergories
Development of novel therapiesRisk reduction intervention
Understanding Underlying Disease
Disease Type
Alzheimer's Disease (AD)CPEC Review Info
| Reference ID | 49 |
|---|---|
| Researcher | Reside Team |
| Published | 12/06/2023 |
Data
| Status / Stage | Active |
|---|---|
| Funder/Grant study page | Alzheimer's Society |
| Contracted Centre | University of Dundee |
| Funding Amount | £85,000.00 |
Abstract
Researchers believe the build up of proteins amyloid and tau damage the brain cells of people with Alzheimer’s disease. Dr Harvey aims to understand more about whether the anti-obesity hormone, leptin could help to protect against this damage. The research team will be using a number of cell and mouse models of Alzheimer’s disease that replicate the build-up of tau proteins seen in people with the condition. They aim to understand whether leptin protects brain cells from damaged caused by the build-up of tau that interrupts communication between the cells.We know more about dementia today than ever before. However we still have no treatment that can slow down or stop the progression of the condition.This study will help us to understand more about the role of tau in Alzheimer’s disease and tell us more about the potential of leptin as a new treatment.
Aims
To understand whether leptin protects brain cells from damaged caused by the build-up of tau that interrupts communication between the cells.We know more about dementia today than ever before. However we still have no treatment that can slow down or stop the progression of the condition.This study will help us to understand more about the role of tau in Alzheimer’s disease and tell us more about the potential of leptin as a new treatment.