A new collaborative ultra-high field MRI facility for dementia and neuroscience research
Award Number
MR/M008983/1Programme
Research GrantStatus / Stage
ActiveDates
1 April 2015 -30 September 2016
Duration (calculated)
01 years 05 monthsFunder(s)
MRC (UKRI)Funding Amount
£6,950,000.00Funder/Grant study page
MRC UKRIContracted Centre
University of CambridgePrincipal Investigator
Dr Rowe, JamesPI Contact
james.rowe@mrc-cbu.cam.ac.ukPI ORCID
0000-0003-4710-4694WHO Catergories
Tools and methodologies for interventionsUnderstanding Underlying Disease
Disease Type
Alzheimer's Disease (AD)CPEC Review Info
| Reference ID | 268 |
|---|---|
| Researcher | Reside Team |
| Published | 12/06/2023 |
Data
| Award Number | MR/M008983/1 |
|---|---|
| Status / Stage | Active |
| Start Date | 20150401 |
| End Date | 20160930 |
| Duration (calculated) | 01 years 05 months |
| Funder/Grant study page | MRC UKRI |
| Contracted Centre | University of Cambridge |
| Funding Amount | £6,950,000.00 |
Abstract
The resolution of 7T MRI will be used to study the pathogenesis of dementia, mechanisms of resilience, and response to therapy in terms of structure (volumetric and diffusion weighted), function (BOLD) and spectroscopy. Sensitivity to iron deposition by quantitative susceptibility mapping is especially relevant to Alzheimer’s disease, while structural and functional changes in vasculature will be examined as markers and targets in stoke, dementia and Huntington’s disease. We will delineate the aetiological role of small but critical subcortical structures (eg hypothalamus, brainstem nuclei, hippocampal subfields). Columnar and laminar resolution of 7T fMRI will be used to understand the neuronal code, testing the predicted functional dissociations between cortical layers for hierarchical information processing. The cross linking of neurochemistry (MRS) with functional and structural data will reveal mechanisms of individual differences, in health and disorders, and potential stratification of therapeutic strategies. The new facility is part of the UK7T network, to promote knowledge transfer, data sharing, training, and coordinated of magnet supply. WBIC and CBSU have Master Research Agreements with Siemens and costs follow a Siemens 7T review, but tendering is open to all manufacturers. We require a minimum of 70mT/m gradients, 8 channel parallel transmission, 32 channel receiver, multinuclear spectroscopy and high order shimming. WBIC is controlled through a Clinical Radiology Information system to collect and monitor data, research protocols and scheduled transfer to PACS for long term secure storage, and secure access control. The proposed high performance informatics hub (data management plan) proposes to increase UoC data analysis capacity from 256 to 1024×16 Gb cores, fast user access to data and efficient parallel processing (using GRIDengine). A new informatics hub enhances integration with NHS systems and high volume data sharing with multisites (eg UKDP).
Aims
We will delineate the aetiological role of small but critical subcortical structures (eg hypothalamus, brainstem nuclei, hippocampal subfields). Columnar and laminar resolution of 7T fMRI will be used to understand the neuronal code, testing the predicted functional dissociations between cortical layers for hierarchical information processing. The cross linking of neurochemistry (MRS) with functional and structural data will reveal mechanisms of individual differences, in health and disorders, and potential stratification of therapeutic strategies. The new facility is part of the UK7T network, to promote knowledge transfer, data sharing, training, and coordinated of magnet supply. WBIC and CBSU have Master Research Agreements with Siemens and costs follow a Siemens 7T review, but tendering is open to all manufacturers. We require a minimum of 70mT/m gradients, 8 channel parallel transmission, 32 channel receiver, multinuclear spectroscopy and high order shimming. WBIC is controlled through a Clinical Radiology Information system to collect and monitor data, research protocols and scheduled transfer to PACS for long term secure storage, and secure access control. The proposed high performance informatics hub (data management plan) proposes to increase UoC data analysis capacity from 256 to 1024×16 Gb cores, fast user access to data and efficient parallel processing (using GRIDengine). A new informatics hub enhances integration with NHS systems and high volume data sharing with multisites (eg UKDP).