Perseverometry: a novel performance marker in dementia
Award Number
G0902237Programme
Research GrantStatus / Stage
CompletedDates
1 December 2010 -30 November 2011
Duration (calculated)
00 years 11 monthsFunder(s)
MRC (UKRI)Funding Amount
£89,083.00Funder/Grant study page
MRC UKRIContracted Centre
St George's University of LondonPrincipal Investigator
Dr Garrard, PeterPI Contact
paprofessorgarrard@gmail.comPI ORCID
0000-0001-8268-9718WHO Catergories
Development of novel therapiesDisease Type
Alzheimer's Disease (AD)CPEC Review Info
| Reference ID | 276 |
|---|---|
| Researcher | Reside Team |
| Published | 12/06/2023 |
Data
| Award Number | G0902237 |
|---|---|
| Status / Stage | Completed |
| Start Date | 20101201 |
| End Date | 20111130 |
| Duration (calculated) | 00 years 11 months |
| Funder/Grant study page | MRC UKRI |
| Contracted Centre | St George's University of London |
| Funding Amount | £89,083.00 |
Abstract
Perseveration is an abnormal form of behaviour in which a speaker excessively repeats the same words, phrases or actions. Perseverative speech is a common presenting feature of Alzheimer s disease (AD) and becomes more prominent as the condition progresses. Recording the occurrence and severity of such behaviour would thus provide not only a measurable diagnostic marker of AD, but also a means of monitoring the patient s clinical course. The latter would be particularly important when evaluating the response to disease-modifying treatments. Continuous recording of an individual s speech in a real world setting, however, would not only violate the privacy of patients and their associates or carers, but would be difficult to interpret without manually segmenting the sources of recorded speech. A data source that was both devoid of linguistic meaning and automatically interpretable using signal processing technology can be achieved by recording acoustic energy rather than speech. The present study aims to develop and test a device and analytical method for capturing and interpreting this information in real world environments, allowing perseverative speech to be detected and quantified.
Aims
Perseveration is an abnormal form of behaviour in which a speaker excessively repeats the same words, phrases or actions. Perseverative speech is a common presenting feature of Alzheimer s disease (AD) and becomes more prominent as the condition progresses. Recording the occurrence and severity of such behaviour would thus provide not only a measurable diagnostic marker of AD, but also a means of monitoring the patient s clinical course. The latter would be particularly important when evaluating the response to disease-modifying treatments. Continuous recording of an individual s speech in a real world setting, however, would not only violate the privacy of patients and their associates or carers, but would be difficult to interpret without manually segmenting the sources of recorded speech. A data source that was both devoid of linguistic meaning and automatically interpretable using signal processing technology can be achieved by recording acoustic energy rather than speech. The present study aims to develop and test a device and analytical method for capturing and interpreting this information in real world environments, allowing perseverative speech to be detected and quantified.